There's a release of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors during the dorsal horn to minimize afferent agony transmission and make analgesia. Thus, medicine like clonidine that target alpha-2 receptors can affect the transmission of suffering. : linked to, served by, or obtainable via https://alexiscwnet.theideasblog.com/32541310/onolidine-an-overview