Limb-threatening or crucial limb ischemia (CLI) is manifested by Long-term (more than two weeks) ischemic rest ache, ischemic wounds or tissue loss, or gangrene in a single or both equally legs. Ischemic rest agony typically takes place soon immediately after falling asleep; the affected person is awakened by burning ache https://www.sgvascularctr.com/treatment-of-peripheral-artery-disease-pad-in-singapore-a-comprehensive-guide/