Pentobarbital will lessen the extent or effect of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Robust or reasonable CYP3A4 inducers may raise rate of diazepam elimination; thus, efficacy of diazepam may be decreased. pentobarbital will lower the extent or outcome of itraconazole by influencing hepatic/intestinal enzyme CYP3A4 https://tupenie887afl3.bcbloggers.com/profile