There is a launch of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors in the dorsal horn to minimize afferent suffering transmission and deliver analgesia. Therefore, medicine like clonidine that target alpha-2 receptors can influence the transmission of discomfort. This doc doesn't comprise all attainable interactions. https://philipn739ofa4.wikigdia.com/user