Butabarbital improves toxicity of methoxyflurane by rising metabolism. Contraindicated. Enhanced metabolism of methoxyflurane to nephrotoxic compounds. butabarbital will lower the extent or outcome of conivaptan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. butabarbital will reduce the extent or outcome of hydrocortisone by influencing hepatic/intestinal... https://eugeneo094mqp4.wikicorrespondent.com/user